Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.83 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxylamine SCHEMBL17540680 | 1.00 | BLM (1.00) | BLMCYP2D6CHRM2CHRM1CHRM4 | |
| Doxylamine SCHEMBL1172924 | 1.00 | BLM (1.00) | BLMCYP2D6CHRM2CHRM1CHRM4 | |
| Doxylamine SCHEMBL12959067 | 0.91 | CHRM2 (1.00) | BLMCYP2D6CHRM2CHRM1CHRM4 | |
| Doxylamine SCHEMBL30702275 | 0.91 | CHRM2 (1.00) | BLMCYP2D6CHRM2CHRM1CHRM4 | |
| Doxylamine SCHEMBL4709 | 0.91 | CHRM2 (1.00) | BLMCYP2D6CHRM2CHRM1CHRM4 | |
| Doxylamine SCHEMBL30116312 | 0.91 | CHRM2 (1.00) | BLMCYP2D6CHRM2CHRM1CHRM4 | |
| Doxylamine SCHEMBL17047020 | 0.90 | CHRM2 (0.97) | BLMCYP2D6CHRM2CHRM1CHRM4 | |
| Doxylamine SCHEMBL2529254 | 0.85 | CYP2D6 (0.72) | BLMCYP2D6CHRM2CHRM1CHRM4 | |
| Doxylamine SCHEMBL29538969 | 0.84 | CYP2D6 (0.71) | BLMCYP2D6CHRM2CHRM1CHRM4 | |
| Pyrilamine SCHEMBL3134257 | 0.83 | CYP2D6 (0.68) | BLMCYP2D6CHRM2CHRM1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4193 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4734952-A1 | ORAL TABLET WITH IMPROVED UNIFORMITY OF CONTENT OF ACTIVES | Fertin Pharma A/S (DK) | 2026-05-06 | — | — | EP | claimed |
| US-12605348-B2 | Pharmaceutical formulations of naproxen for soft gel encapsulation and combinations thereof | CATALENT ONTARIO LIMITED (CA) | 2026-04-21 | — | — | US | claimed |
| EP-4724114-A1 | CYANOACRYLATE ADHESIVE KITS | Chemence, Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| US-20260090584-A1 | SYSTEMS AND METHODS FOR ESTIMATING AEROSOLIZATION EMISSION | SCIENTIFIC HORIZONS CONSULTING LLC (US) | 2026-04-02 | — | — | US | claimed |
| EP-4716527-A1 | A MULTIPLE UNIT ORAL DOSAGE FORM OF DOXYLAMINE SUCCINATE AND PYRIDOXINE HYDROCHLORIDE FREE OF TITANIUM DIOXIDE | Italfarmaco SpA (IT) | 2026-04-01 | — | — | EP | claimed |
| WO-2026041855-A1 | CYANOACRYLATE ADHESIVE KITS | CHEMENCE, INC. (US) | 2026-02-26 | — | — | WO | claimed |
| US-20250325483-A1 | FLOWPACK WITH COMPOSITION FOR IMPROVED TASTE MASKING OF ACTIVES | FERTIN PHARMA AS (DK) | 2025-10-23 | — | — | US | claimed |
| EP-4626808-A1 | AN INDIVIDUAL DOSE POD | Haleon US Holdings LLC (US) | 2025-10-08 | — | — | EP | claimed |
| EP-4590371-A2 | SYSTEMS AND METHODS FOR ESTIMATING AEROSOLIZATION EMISSION | Scientific Horizons consulting LLC (US) | 2025-07-30 | — | — | EP | claimed |
| EP-4565232-A1 | A STABLE TABLET-IN-TABLET COMPOSITION FOR NAUSEA VOMITING IN PREGNANCY | Akums Drugs And Pharmaceuticals Limited (IN) | 2025-06-11 | — | — | EP | claimed |
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | claimed |
| US-4882151-A | MASKING OF FIBROUS MOUTHFEEL AND UNPLEASANT TASTE | WARNER LAMBERT CO. (US) | 1989-11-21 | — | — | US | claimed |
| EP-0132472-B1 | MEDICATED PRODUCTS CONTAINING A MAGNESIUM TRISILICATE ADSORBENT WITH A MEDICAMENT DRUG ADSORBED THEREON | WARNER-LAMBERT COMPANY (US) | 1989-06-21 | — | — | EP | claimed |
| US-4753800-A | DRUGS ADSORBED ONTO MAGNESIUM ALUMINUM STEARATE | WARNER-LAMBERT COMPANY (US) | 1988-06-28 | — | — | US | claimed |
| EP-0219458-A2 | Medicament adsorbates and their preparation | WARNER-LAMBERT COMPANY (US) | 1987-04-22 | — | — | EP | claimed |
| US-4642231-A | Magnesium trisilicate suitable for preparation of medicament adsorbates of antihistamines | WARNER-LAMBERT COMPANY (US) | 1987-02-10 | — | — | US | claimed |
| EP-0138882-A1 | IMPROVED ORGANOSOLV PROCESS FOR HYDROLYTIC DECOMPOSITION OF LIGNOCELLULOSIC AND STARCH MATERIALS | O'SHAUGHNESSY, James Patrick (US) | 1985-05-02 | — | — | EP | claimed |
| EP-0132472-A1 | Medicated products containing a magnesium trisilicate adsorbent with a medicament drug adsorbed thereon | WARNER-LAMBERT COMPANY (US) | 1985-02-13 | — | — | EP | claimed |
| WO-1984003304-A1 | IMPROVED ORGANOSOLV PROCESS FOR HYDROLYTIC DECOMPOSITION OF LIGNOCELLULOSIC AND STARCH MATERIALS | SHAUGHNESSY JAMES PATRICK O (US) | 1984-08-30 | — | — | WO | claimed |
| US-4269835-A | Nasal composition for relieving nasal distress | WHITTLE BARRY J | 1981-05-26 | — | — | US | claimed |