Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 8/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 2/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10156776 | 0.86 | BACE1 (0.71) | BACE1SLC6A4SLC6A3SLC6A2BACE2 | |
| SCHEMBL5330236 | 0.75 | BACE1 (0.70) | BACE1KCNH2 | |
| SCHEMBL3617743 | 0.74 | TAAR1 (0.60) | BACE1 | |
| SCHEMBL3617749 | 0.74 | TAAR1 (0.60) | BACE1 | |
| SCHEMBL10154760 | 0.71 | BACE1 (0.49) | BACE1SLC6A4SLC6A3SLC6A2KCNH2 | |
| SCHEMBL28172966 | 0.69 | SLC6A4 (0.49) | BACE1SLC6A4SLC6A3SLC6A2CTSD | |
| SCHEMBL5052720 | 0.69 | BACE1 (0.65) | BACE1KCNH2KDM1A | |
| SCHEMBL12350637 | 0.68 | BACE1 (0.76) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL10195094 | 0.68 | BACE1 (1.00) | BACE1KCNH2 | |
| SCHEMBL10194679 | 0.68 | SLC6A4 (0.54) | SLC6A4SLC6A3SLC6A2KCNH2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970255-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | Galapagos NV (BE) | 2016-01-20 | — | — | EP | claimed |
| WO-2014139882-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2014-09-18 | — | — | WO | claimed |