Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 20/20 | 0.81 |
| ▸ | CDK9 | P50750 | 20/20 | 0.81 |
| ▸ | CDK1 | P06493 | 1/20 | 0.75 |
| ▸ | CDK4 | P11802 | 1/20 | 0.75 |
| ▸ | CDK2 | P24941 | 1/20 | 0.75 |
| ▸ | CDK8 | P49336 | 1/20 | 0.75 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16052149 | 0.93 | CCNT1 (0.76) | CCNT1CDK9CDK1CDK4CDK2 | |
| SCHEMBL16050920 | 0.90 | CCNT1 (0.76) | CCNT1CDK9CDK1CDK4CDK2 | |
| SCHEMBL16050794 | 0.90 | CCNT1 (1.00) | CCNT1CDK9 | |
| SCHEMBL19465625 | 0.89 | CCNT1 (0.85) | CCNT1CDK9CDK1CDK4CDK2 | |
| SCHEMBL16051480 | 0.88 | CCNT1 (1.00) | CCNT1CDK9CDK1CDK4CDK2 | |
| SCHEMBL16043006 | 0.87 | CCNT1 (1.00) | CCNT1CDK9 | |
| SCHEMBL16051154 | 0.87 | CCNT1 (1.00) | CCNT1CDK9 | |
| SCHEMBL16052065 | 0.87 | CCNT1 (0.78) | CCNT1CDK9 | |
| SCHEMBL16050560 | 0.87 | CCNT1 (0.78) | CCNT1CDK9 | |
| SCHEMBL16043020 | 0.87 | CCNT1 (1.00) | CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970278-A1 | PYRROLO[2,3-B]PYRIDINE CDK9 KINASE INHIBITORS | AbbVie Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014139328-A1 | PYRROLO[2,3-B]PYRIDINE CDK9 KINASE INHIBITORS | ABBVIE INC. (US) | 2014-09-18 | — | — | WO | disclosed |