Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054111 | 0.86 | — | — | |
| SCHEMBL24981405 | 0.76 | MEN1 (0.39) | MEN1MAPK1KMT2ACACNA1HCTSK | |
| SCHEMBL13924261 | 0.76 | MEN1 (0.39) | MEN1MAPK1KMT2ACACNA1HCTSK | |
| SCHEMBL8002198 | 0.75 | MEN1 (0.38) | MEN1MAPK1KMT2ACACNA1HCTSK | |
| SCHEMBL6050963 | 0.75 | MEN1 (0.38) | MEN1MAPK1KMT2ACACNA1HCTSK | |
| SCHEMBL1537645 | 0.75 | MEN1 (0.38) | MEN1MAPK1KMT2ACACNA1HCTSK | |
| SCHEMBL380051 | 0.75 | MEN1 (0.38) | MEN1MAPK1KMT2ACACNA1HCTSK | |
| SCHEMBL13302345 | 0.75 | MEN1 (0.38) | MEN1MAPK1KMT2ACACNA1HCTSK | |
| SCHEMBL2617503 | 0.75 | MEN1 (0.38) | MEN1MAPK1KMT2ACACNA1HCTSK | |
| SCHEMBL8372247 | 0.75 | MEN1 (0.38) | MEN1MAPK1KMT2ACACNA1HCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970335-A1 | MACROCYCLIC AND BICYCLIC INHIBITORS OF HEPATITIS C VIRUS | Gilead Sciences, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014145095-A1 | MACROCYCLIC AND BICYCLIC INHIBITORS OF HEPATITIS C VIRUS | GILEAD SCIENCES, INC. (US) | 2014-09-18 | — | — | WO | disclosed |