Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 1.00 |
| ▸ | RAB9A | P51151 | 13/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 1.00 |
| ▸ | MAPT | P10636 | 10/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | CASP3 | P42574 | 1/20 | 1.00 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 1.00 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 1.00 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 3/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | PPARG | P37231 | 1/20 | 0.65 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.65 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5534479 | 0.85 | KDM4E (0.73) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL5539829 | 0.84 | MAPT (0.70) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL17732649 | 0.81 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL11888641 | 0.78 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL4918623 | 0.77 | PTPN7 (0.77) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL14315172 | 0.76 | MAPT (1.00) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL6228748 | 0.76 | F10 (0.73) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL3403002 | 0.76 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL29858763 | 0.76 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL5935569 | 0.76 | MAPT (0.79) | NPC1RAB9ASMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376430-B2 | Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2016-06-28 | — | — | US | disclosed |
| US-9333193-B2 | Compositions and methods for treating tuberculosis | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2016-05-10 | — | — | US | disclosed |
| US-8835644-B2 | Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2014-09-16 | — | — | US | disclosed |