Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 11/20 | 0.56 |
| ▸ | HSP90B1 | P14625 | 11/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16136365 | 0.88 | HSP90AA1 (0.58) | HSP90AA1HSP90B1TP53BRD4ADRA2C | |
| SCHEMBL16133643 | 0.85 | HSP90AA1 (0.55) | HSP90AA1HSP90B1TP53BRD4ADRA2C | |
| SCHEMBL20625806 | 0.84 | HSP90AA1 (0.53) | HSP90AA1HSP90B1TP53BRD4ADRA2C | |
| SCHEMBL16768685 | 0.81 | HSP90AA1 (0.50) | HSP90AA1HSP90B1TP53BRD4ADRA2C | |
| SCHEMBL16136339 | 0.79 | HSP90AA1 (0.54) | HSP90AA1HSP90B1TP53BRD4ADRA2C | |
| SCHEMBL16133634 | 0.76 | HSP90AA1 (0.52) | HSP90AA1HSP90B1TP53BRD4ADRA2C | |
| SCHEMBL6959787 | 0.75 | HSP90AA1 (0.53) | HSP90AA1HSP90B1LMNA | |
| SCHEMBL19413280 | 0.75 | HSP90AA1 (0.47) | HSP90AA1HSP90B1TP53BRD4HSP90AB1 | |
| SCHEMBL16136314 | 0.73 | HSP90AA1 (0.54) | HSP90AA1HSP90B1HSP90AB1LMNA | |
| SCHEMBL12851364 | 0.71 | NPC1 (0.79) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014144747-A1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2014-09-18 | — | — | WO | disclosed |