SCHEMBL16066071

SCHEMBL16066071

COC[C@@H](Cn1cnc2c(=O)[nH]c(N)nc21)OCP(=O)(O)Oc1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 19/20 0.63
PNP P00491 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16062923 0.91 HPRT1 (0.59) HPRT1
SCHEMBL16063284 0.91 HPRT1 (0.61) HPRT1PNP
SCHEMBL19508679 0.90 HPRT1 (0.68) HPRT1PNP
SCHEMBL14669229 0.90 HPRT1 (0.66) HPRT1
SCHEMBL14669228 0.90 HPRT1 (0.66) HPRT1
SCHEMBL14665400 0.88 HPRT1 (0.64) HPRT1
SCHEMBL14665370 0.88 HPRT1 (0.64) HPRT1
SCHEMBL14669071 0.88 HPRT1 (0.71) HPRT1
SCHEMBL14669070 0.88 HPRT1 (0.71) HPRT1
SCHEMBL14669187 0.88 HPRT1 (0.71) HPRT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014143643-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION (US) 2014-09-18 WO disclosed