Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.83 |
| ▸ | NEK2 | P51955 | 1/20 | 0.83 |
| ▸ | AURKA | O14965 | 1/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.66 |
| ▸ | BRD4 | O60885 | 15/20 | 0.66 |
| ▸ | JAK2 | O60674 | 3/20 | 0.62 |
| ▸ | FLT3 | P36888 | 2/20 | 0.62 |
| ▸ | CCNK | O75909 | 1/20 | 0.62 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.62 |
| ▸ | CDK2 | P24941 | 1/20 | 0.62 |
| ▸ | CCND3 | P30281 | 1/20 | 0.62 |
| ▸ | CDK9 | P50750 | 1/20 | 0.62 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.62 |
| ▸ | JAK1 | P23458 | 3/20 | 0.61 |
| ▸ | BRD2 | P25440 | 3/20 | 0.61 |
| ▸ | JAK3 | P52333 | 3/20 | 0.61 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.61 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.61 |
| ▸ | BUB1B | O60566 | 1/20 | 0.59 |
| ▸ | RET | P07949 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25549741 | 0.87 | AXL (0.84) | AXLNEK2AURKAAURKBJAK2 | |
| SCHEMBL1607653 | 0.84 | BRD4 (0.66) | AXLNEK2BRD4JAK2FLT3 | |
| SCHEMBL264403 | 0.83 | BRD4 (0.78) | BRD4JAK2FLT3JAK1BRD2 | |
| SCHEMBL30372758 | 0.81 | AXL (0.69) | AXLNEK2AURKAAURKBBRD4 | |
| SCHEMBL20500090 | 0.81 | BRD4 (0.63) | AXLNEK2BRD4JAK2FLT3 | |
| SCHEMBL25550588 | 0.81 | AXL (0.60) | AXLNEK2AURKAAURKBCDK9 | |
| SCHEMBL270128 | 0.81 | CCNK (0.71) | BRD4JAK2CCNKCCNA2CDK2 | |
| SCHEMBL30306457 | 0.80 | BRD4 (0.77) | BRD4JAK2FLT3CCNKCCNA2 | |
| Hydrochloric Acid SCHEMBL264699 | 0.80 | CCNK (0.70) | BRD4JAK2CCNKCCNA2CDK2 | |
| Dubermatinib SCHEMBL29394359 | 0.80 | AXL (1.00) | AXLNEK2AURKAAURKBJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304422-B2 | Compositions and methods for inhibition of the JAK pathway | RIGEL PHARMACEUTICALS, INC. (US) | 2012-11-06 | — | — | US | claimed |
| US-7947698-B2 | Prevent trabsplant rejection; autoimmune diseases | RIGEL PHARMACEUTICALS, INC. (US) | 2011-05-24 | — | — | US | claimed |
| US-20110082146-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | US | claimed |
| US-20080279867-A1 | Prevent trabsplant rejection; autoimmune diseases | RIGEL PHARMACEUTICALS, INC. | 2008-11-13 | — | — | US | claimed |
| US-8304422-B2 | Compositions and methods for inhibition of the JAK pathway | RIGEL PHARMACEUTICALS, INC. (US) | 2012-11-06 | — | — | US | disclosed |
| US-7947698-B2 | Prevent trabsplant rejection; autoimmune diseases | RIGEL PHARMACEUTICALS, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-20110082146-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | US | disclosed |
| US-20080279867-A1 | Prevent trabsplant rejection; autoimmune diseases | RIGEL PHARMACEUTICALS, INC. | 2008-11-13 | — | — | US | disclosed |
| WO-2008118822-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082146-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | JAK3, JAK2, JAK1 | AXL 1118/4885NEK2 628/4885AURKA 751/4885 |
| US-20080279867-A1 | Prevent trabsplant rejection; autoimmune diseases | JAK3, JAK1, JAK2 | AXL 1478/4885NEK2 2976/4885AURKA 3610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.