Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.61 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 3/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17020101 | 1.00 | SPHK1 (0.61) | SPHK1HSD11B2BRD4CES2HCRTR2 | |
| SCHEMBL18959559 | 1.00 | SPHK1 (0.61) | SPHK1HSD11B2BRD4CES2HCRTR2 | |
| SCHEMBL9915254 | 1.00 | SPHK1 (0.61) | SPHK1HSD11B2BRD4CES2HCRTR2 | |
| SCHEMBL18959562 | 0.99 | SPHK1 (0.60) | SPHK1HSD11B2BRD4CES2HCRTR2 | |
| SCHEMBL16071281 | 0.95 | SPHK1 (0.58) | SPHK1HSD11B2BRD4HCRTR2ALDH1A1 | |
| SCHEMBL8042623 | 0.91 | SPHK1 (0.53) | SPHK1HSD11B2BRD4CES2ALDH1A1 | |
| SCHEMBL8054065 | 0.91 | SPHK1 (0.53) | SPHK1HSD11B2BRD4CES2ALDH1A1 | |
| SCHEMBL16053956 | 0.90 | SPHK1 (0.50) | SPHK1HSD11B2BRD4HCRTR2CHRM2 | |
| SCHEMBL10211328 | 0.89 | SPHK1 (0.54) | SPHK1HSD11B2BRD4HCRTR2ALDH1A1 | |
| SCHEMBL11956427 | 0.89 | SPHK1 (0.54) | SPHK1HSD11B2BRD4HCRTR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014140787-A2 | METHODS FOR THE SYNTHESIS OF SPHINGOMYELINS AND DIHYDROSPHINGOMYELINS | CERENIS THERAPEUTICS HOLDING SA (FR) | 2014-09-18 | — | — | WO | disclosed |