Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL828491 | 0.80 | TSHR (0.67) | TSHRKDM4EATMNPC1RAB9A | |
| SCHEMBL16795707 | 0.77 | TSHR (0.53) | TSHRPOLBKDM4EATMNPC1 | |
| SCHEMBL1468284 | 0.77 | POLB (0.64) | TSHRPOLBKDM4EATMNPC1 | |
| SCHEMBL16071339 | 0.77 | CTNNB1 (0.44) | TSHRNPC1RAB9AKMT2ACTNNB1 | |
| SCHEMBL2496047 | 0.76 | TSHR (0.72) | TSHRKDM4EATMNPC1RAB9A | |
| SCHEMBL18101240 | 0.76 | KDM4E (0.70) | TSHRKDM4EATMNPC1RAB9A | |
| SCHEMBL18101248 | 0.76 | KDM4E (0.70) | TSHRKDM4EATMNPC1RAB9A | |
| SCHEMBL18101284 | 0.76 | KDM4E (0.70) | TSHRKDM4EATMNPC1RAB9A | |
| SCHEMBL28530741 | 0.76 | TSHR (0.61) | TSHRKDM4EATMNPC1RAB9A | |
| SCHEMBL18101244 | 0.76 | KDM4E (0.70) | TSHRKDM4EATMNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014145207-A1 | SUBSTITUTED GEMCITABINE BICYCLIC AMIDE ANALOGS AND TREATMENT METHODS USING SAME | OHIO STATE INNOVATION FOUNDATION (US) | 2014-09-18 | — | — | WO | disclosed |