Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 1.00 |
| ▸ | CDK4 | P11802 | 19/20 | 1.00 |
| ▸ | CCND1 | P24385 | 19/20 | 1.00 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20968133 | 0.99 | CDK2 (0.99) | CDK2CDK4CCND1CCNE1 | |
| SCHEMBL16076733 | 0.91 | CDK4 (0.99) | CDK2CDK4CCND1 | |
| SCHEMBL22005383 | 0.91 | CDK2 (0.89) | CDK2CDK4CCND1CCNE1 | |
| SCHEMBL16074619 | 0.91 | CDK4 (1.00) | CDK2CDK4CCND1 | |
| SCHEMBL16074641 | 0.91 | CDK4 (1.00) | CDK2CDK4CCND1 | |
| SCHEMBL16074621 | 0.90 | CDK2 (1.00) | CDK2CDK4CCND1CCNE1 | |
| SCHEMBL16074600 | 0.89 | CDK2 (1.00) | CDK2CDK4CCND1CCNE1 | |
| SCHEMBL19036384 | 0.88 | CDK2 (1.00) | CDK2CDK4CCND1CCNE1 | |
| SCHEMBL16074612 | 0.88 | CDK2 (1.00) | CDK2CDK4CCND1CCNE1 | |
| SCHEMBL16074630 | 0.87 | CDK2 (1.00) | CDK2CDK4CCND1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230381189-A1 | TRANSIENT PROTECTION OF NORMAL CELLS DURING CHEMOTHERAPY | G1 THERAPEUTICS, INC. (US) | 2023-11-30 | — | — | US | disclosed |
| US-20230381189-A1 | TRANSIENT PROTECTION OF NORMAL CELLS DURING CHEMOTHERAPY | G1 THERAPEUTICS, INC. (US) | 2023-11-30 | — | — | US | disclosed |
| US-20230248733-A1 | HIGHLY ACTIVE ANTI-NEOPLASTIC AND ANTI-PROLIFERATIVE AGENTS | G1 THERAPEUTICS, INC. (US) | 2023-08-10 | — | — | US | disclosed |
| US-20230248733-A1 | HIGHLY ACTIVE ANTI-NEOPLASTIC AND ANTI-PROLIFERATIVE AGENTS | G1 THERAPEUTICS, INC. (US) | 2023-08-10 | — | — | US | disclosed |
| US-11717523-B2 | Transient protection of normal cells during chemotherapy | G1 THERAPEUTICS, INC. (US) | 2023-08-08 | — | — | US | disclosed |
| US-11717523-B2 | Transient protection of normal cells during chemotherapy | G1 THERAPEUTICS, INC. (US) | 2023-08-08 | — | — | US | disclosed |
| US-20210299130-A1 | TRANSIENT PROTECTION OF NORMAL CELLS DURING CHEMOTHERAPY | G1 THERAPEUTICS, INC. (US) | 2021-09-30 | — | — | US | disclosed |
| US-11040042-B2 | Transient protection of normal cells during chemotherapy | G1 THERAPEUTICS, INC. (US) | 2021-06-22 | — | — | US | disclosed |
| US-10966984-B2 | Transient protection of normal cells during chemotherapy | G1 THERAPEUTICS, INC. (US) | 2021-04-06 | — | — | US | disclosed |
| US-20200345743-A1 | HIGHLY ACTIVE ANTI-NEOPLASTIC AND ANTI-PROLIFERATIVE AGENTS | G1 THERAPEUTICS, INC. (US) | 2020-11-05 | — | — | US | disclosed |
| US-20140275066-A1 | Transient Protection of Normal Cells During Chemotherapy | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140275067-A1 | Transient Protection of Normal Cells During Chemotherapy | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140275067-A1 | Transient Protection of Normal Cells During Chemotherapy | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140271466-A1 | HSPC-Sparing Treatments for RB-Positive Abnormal Cellular Proliferation | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140275066-A1 | Transient Protection of Normal Cells During Chemotherapy | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140271466-A1 | HSPC-Sparing Treatments for RB-Positive Abnormal Cellular Proliferation | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | US | disclosed |
| WO-2014144740-A2 | HIGHLY ACTIVE ANTI-NEOPLASTIC AND ANTI-PROLIFERATIVE AGENTS | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014144847-A2 | HSPC-SPARING TREATMENTS FOR RB-POSITIVE ABNORMAL CELLULAR PROLIFERATION | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| US-20140271460-A1 | Highly Active Anti-Neoplastic and Anti-Proliferative Agents | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140271460-A1 | Highly Active Anti-Neoplastic and Anti-Proliferative Agents | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10966984-B2 | Transient protection of normal cells during chemotherapy | CDK6, CCNC, MCL1 | CDK2 10/4885CDK4 6/4885CCND1 41/4885 |
| US-20230248733-A1 | HIGHLY ACTIVE ANTI-NEOPLASTIC AND ANTI-PROLIFERATIVE AGENTS | MKI67, PCNA, HRAS | CDK2 69/4885CDK4 16/4885CCND1 36/4885 |
| US-20200345743-A1 | HIGHLY ACTIVE ANTI-NEOPLASTIC AND ANTI-PROLIFERATIVE AGENTS | MKI67, PCNA, HRAS | CDK2 69/4885CDK4 16/4885CCND1 36/4885 |
| US-20140275067-A1 | Transient Protection of Normal Cells During Chemotherapy | CDK6, CCNC, MCL1 | CDK2 10/4885CDK4 6/4885CCND1 41/4885 |
| US-20230381189-A1 | TRANSIENT PROTECTION OF NORMAL CELLS DURING CHEMOTHERAPY | CDK6, CCNC, MCL1 | CDK2 10/4885CDK4 6/4885CCND1 41/4885 |
| US-20210299130-A1 | TRANSIENT PROTECTION OF NORMAL CELLS DURING CHEMOTHERAPY | CDK6, CCNC, MCL1 | CDK2 10/4885CDK4 6/4885CCND1 41/4885 |
| US-20140271466-A1 | HSPC-Sparing Treatments for RB-Positive Abnormal Cellular Proliferation | RB1, CDK4, CDKN1A | CDK2 13/4885CDK4 2/4885CCND1 84/4885 |
| US-20140271460-A1 | Highly Active Anti-Neoplastic and Anti-Proliferative Agents | MKI67, PCNA, HRAS | CDK2 69/4885CDK4 16/4885CCND1 36/4885 |
| US-20140275066-A1 | Transient Protection of Normal Cells During Chemotherapy | CDK6, CCNC, MCL1 | CDK2 10/4885CDK4 6/4885CCND1 41/4885 |
| US-11040042-B2 | Transient protection of normal cells during chemotherapy | CDK6, CCNC, MCL1 | CDK2 10/4885CDK4 6/4885CCND1 41/4885 |
| US-11717523-B2 | Transient protection of normal cells during chemotherapy | CDK6, CCNC, MCL1 | CDK2 10/4885CDK4 6/4885CCND1 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.