Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.80 |
| ▸ | MPC2 | O95563 | 2/20 | 0.80 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.80 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16075632 | 1.00 | PPARG (0.80) | PPARGMPC2CYP2C8CYP2C9NPC1 | |
| SCHEMBL16075636 | 1.00 | PPARG (0.80) | PPARGMPC2CYP2C8CYP2C9NPC1 | |
| SCHEMBL18541485 | 0.89 | PPARG (1.00) | PPARGMPC2CYP2C8CYP2C9NPC1 | |
| SCHEMBL29376450 | 0.89 | PPARG (1.00) | PPARGMPC2CYP2C8CYP2C9NPC1 | |
| SCHEMBL623654 | 0.89 | PPARG (1.00) | PPARGMPC2CYP2C8CYP2C9NPC1 | |
| SCHEMBL18541511 | 0.89 | PPARG (1.00) | PPARGMPC2CYP2C8CYP2C9NPC1 | |
| SCHEMBL6931416 | 0.84 | PPARG (0.83) | PPARGMPC2CYP2C8CYP2C9NPC1 | |
| SCHEMBL13504806 | 0.81 | PPARG (0.72) | PPARGMPC2CYP2C8CYP2C9NPC1 | |
| SCHEMBL24212244 | 0.81 | PPARG (0.71) | PPARGMPC2CYP2C8CYP2C9NPC1 | |
| SCHEMBL6930322 | 0.79 | PPARG (0.82) | PPARGMPC2CYP2C8CYP2C9FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170049762-A1 | 5-DEUTERO-2,4-THIAZOLIDINEDIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | POXEL SA (FR) | 2017-02-23 | — | — | US | disclosed |
| US-9416117-B2 | 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same | DEUTERX, LLC (US) | 2016-08-16 | — | — | US | disclosed |
| US-20150284346-A1 | 5-DEUTERO-2,4-THIAZOLIDINEDIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | POXEL SA (FR) | 2015-10-08 | — | — | US | disclosed |
| US-8969581-B2 | 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same | DEUTERX, LLC (US) | 2015-03-03 | — | — | US | disclosed |
| US-20140275180-A1 | 5-DEUTERO-2,4-THIAZOLIDINEDIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | DEUTERX, LLC (US) | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284346-A1 | 5-DEUTERO-2,4-THIAZOLIDINEDIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | SLC5A2, PPARD, DPP4 | PPARG 10/4885MPC2 636/4885CYP2C8 443/4885 |
| US-20140275180-A1 | 5-DEUTERO-2,4-THIAZOLIDINEDIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | SLC5A2, PPARD, DPP4 | PPARG 10/4885MPC2 636/4885CYP2C8 443/4885 |
| US-20170049762-A1 | 5-DEUTERO-2,4-THIAZOLIDINEDIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | SLC5A2, PPARD, DPP4 | PPARG 10/4885MPC2 636/4885CYP2C8 443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.