Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 13/20 | 0.45 |
| ▸ | ATF4 | P18848 | 3/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1608260 | 0.92 | GRIN2B (0.46) | GRIN2BGRIN1HDAC6HDAC3HDAC1 | |
| SCHEMBL1608469 | 0.91 | GRIN2B (0.47) | GRIN2BGRIN1 | |
| SCHEMBL1607718 | 0.84 | HDAC11 (0.54) | ATF4HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL1607731 | 0.82 | GRIN2B (0.42) | GRIN2BGRIN1HDAC6HDAC3HDAC1 | |
| SCHEMBL1608380 | 0.82 | GRIN2B (0.44) | GRIN2BGRIN1HDAC6HDAC3HDAC1 | |
| SCHEMBL1608144 | 0.82 | HDAC6 (0.47) | GRIN2BHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL1608787 | 0.80 | MCL1 (0.43) | ATF4HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL1608639 | 0.80 | GRIN2B (0.45) | GRIN2BGRIN1HDAC6HDAC3HDAC1 | |
| SCHEMBL1607558 | 0.79 | SMN1; SMN2 (0.41) | GRIN2BGRIN1HDAC6HDAC3HDAC1 | |
| SCHEMBL1608372 | 0.79 | GRIN2B (0.42) | GRIN2BGRIN1HDAC6HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150320758-A1 | SELECTIVE INHIBITORS OF HISTONE DEACTYLASE | PHARMACYCLICS LLC | 2015-11-12 | — | — | US | disclosed |
| US-8906954-B2 | Selective inhibitors of histone deacetylase | PHARMACYCLICS, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20140004174-A1 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2014-01-02 | — | — | US | disclosed |
| US-8466193-B2 | Selective inhibitors of histone deacetylase | PHARMACYCLICS, INC. (US) | 2013-06-18 | — | — | US | disclosed |
| US-20110081409-A1 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS LLC | 2011-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110081409-A1 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE | HDAC8, HDAC1, HDAC11 | GRIN2B 2100/4885ATF4 1043/4885GRIN1 1260/4885 |
| US-20150320758-A1 | SELECTIVE INHIBITORS OF HISTONE DEACTYLASE | HDAC8, HDAC1, HDAC5 | GRIN2B 2419/4885ATF4 1773/4885GRIN1 1331/4885 |
| US-20140004174-A1 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE | HDAC8, HDAC1, HDAC11 | GRIN2B 2100/4885ATF4 1043/4885GRIN1 1260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.