Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.38 |
| ▸ | BMP4 | P12644 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29967853 | 0.75 | KDM4E (0.51) | MAPTKDM4EHTTCYP3A4 | |
| SCHEMBL1870141 | 0.69 | MAPT (0.50) | MAPTKDM4ELMNAMEN1HSP90AA1 | |
| SCHEMBL2733510 | 0.69 | IDO1 (0.57) | MAPTKDM4ELMNAMEN1HSP90AA1 | |
| SCHEMBL217044 | 0.65 | MAPT (1.00) | MAPTKDM4ELMNAMEN1HSP90AA1 | |
| SCHEMBL4542842 | 0.64 | MAPT (0.44) | MAPTKDM4ELMNAMEN1HSP90AA1 | |
| SCHEMBL21306393 | 0.63 | PDE10A (0.51) | MAPTKDM4ELMNAMEN1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL28420480 | 0.63 | MAPT (0.94) | MAPTKDM4ELMNAMEN1HSP90AA1 | |
| SCHEMBL30119859 | 0.62 | MAPT (0.50) | MAPTKDM4ELMNAMEN1HSP90AA1 | |
| SCHEMBL1370432 | 0.62 | MAPT (0.50) | MAPTKDM4ELMNAMEN1HSP90AA1 | |
| SCHEMBL2926836 | 0.61 | MAPT (0.89) | MAPTKDM4ELMNAMEN1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8536193-B2 | Inhibitors of AKT activity | MERCK SHARP & DOHME CORP. (US) | 2013-09-17 | — | — | US | disclosed |
| US-20110082135-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME LLC | 2011-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082135-A1 | INHIBITORS OF AKT ACTIVITY | PIK3CA, AKT1S1, AKT1 | MAPT 4667/4885KDM4E 1249/4885LMNA 3011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.