Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.61 |
| ▸ | CDK4 | P11802 | 15/20 | 0.61 |
| ▸ | CCND1 | P24385 | 15/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 13/20 | 0.61 |
| ▸ | CCND3 | P30281 | 5/20 | 0.61 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.61 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.61 |
| ▸ | CDK9 | P50750 | 4/20 | 0.61 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.61 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.51 |
| ▸ | TTK | P33981 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | CCNH | P51946 | 1/20 | 0.50 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.50 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.50 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22570004 | 0.99 | CDK2 (0.63) | CDK2CDK4CCND1CCNE1CCND3 | |
| SCHEMBL4549860 | 0.85 | CDK2 (0.56) | CDK2CDK4CCND1CCNE1CCND3 | |
| SCHEMBL21014427 | 0.85 | CDK2 (0.56) | CDK2CDK4CCND1CCNE1CCND3 | |
| SCHEMBL31252716 | 0.84 | CDK2 (0.57) | CDK2CDK4CCND1CCNE1CCND3 | |
| SCHEMBL15249224 | 0.84 | CDK2 (0.57) | CDK2CDK4CCND1CCNE1CCND3 | |
| SCHEMBL21388312 | 0.83 | CDK2 (0.54) | CDK2CDK4CCND1CCNE1CCND3 | |
| SCHEMBL22570112 | 0.82 | CDK2 (0.66) | CDK2CDK4CCND1CCNE1CCND3 | |
| SCHEMBL25949551 | 0.82 | CDK2 (0.53) | CDK2CDK4CCND1CCNE1CCND3 | |
| SCHEMBL20957562 | 0.81 | CDK2 (0.55) | CDK2CDK4CCND1CCNE1CCND3 | |
| SCHEMBL31073178 | 0.81 | CDK2 (0.55) | CDK2CDK4CCND1CCNE1CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014144326-A1 | TRANSIENT PROTECTION OF NORMAL CELLS DURING CHEMOTHERAPY | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014144740-A2 | HIGHLY ACTIVE ANTI-NEOPLASTIC AND ANTI-PROLIFERATIVE AGENTS | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014144847-A2 | HSPC-SPARING TREATMENTS FOR RB-POSITIVE ABNORMAL CELLULAR PROLIFERATION | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |