Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | NMUR2 | Q9GZQ4 | 2/20 | 0.39 |
| ▸ | NMUR1 | Q9HB89 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | CTSE | P14091 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 2/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 8/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.37 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2399597 | 0.83 | F2 (0.45) | F2NMUR2NMUR1ACEREN | |
| SCHEMBL3658601 | 0.83 | F2 (0.45) | F2NMUR2NMUR1ACEREN | |
| SCHEMBL30434139 | 0.77 | ACE (0.54) | F2NMUR2ACERENACE2 | |
| SCHEMBL30435100 | 0.74 | CAPN1 (0.45) | NMUR2ACERENCAPN1 | |
| SCHEMBL30434874 | 0.73 | ACE (0.54) | F2ACERENACE2 | |
| SCHEMBL2195410 | 0.72 | ACE (0.50) | F2ACERENACE2 | |
| SCHEMBL30434949 | 0.72 | ACE (0.55) | F2ACERENACE2 | |
| SCHEMBL15485412 | 0.72 | F2 (0.41) | F2NMUR2NMUR1ACE | |
| SCHEMBL30435240 | 0.72 | NTSR2 (0.46) | ACEREN | |
| SCHEMBL30434738 | 0.72 | NTSR2 (0.46) | F2NMUR2ACERENCAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014139014-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR ACTIVITY AND VASCULAR PERMEABILITY | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2014-09-18 | — | — | WO | disclosed |