Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16082480 | 0.85 | TP53 (0.81) | TP53LMNAHPGDRXFP1MEN1 | |
| SCHEMBL16082522 | 0.84 | TP53 (0.82) | TP53LMNAHPGDRXFP1MEN1 | |
| SCHEMBL16082518 | 0.82 | TP53 (1.00) | TP53LMNAHPGDMEN1KMT2A | |
| SCHEMBL16082498 | 0.82 | TP53 (0.85) | TP53LMNAHPGDRXFP1MEN1 | |
| SCHEMBL16082494 | 0.82 | TP53 (0.75) | TP53LMNAHPGDRXFP1MEN1 | |
| SCHEMBL16082486 | 0.81 | TP53 (0.77) | TP53LMNAHPGDRXFP1MEN1 | |
| SCHEMBL16082482 | 0.81 | TP53 (0.80) | TP53LMNAHPGDRXFP1MEN1 | |
| SCHEMBL16082478 | 0.81 | TP53 (0.80) | TP53LMNAHPGDMEN1KMT2A | |
| SCHEMBL16082915 | 0.80 | TP53 (0.68) | TP53LMNAHPGDRXFP1MEN1 | |
| SCHEMBL16082484 | 0.80 | TP53 (0.84) | TP53LMNAHPGDRXFP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790188-B2 | Benzimidazole derivatives and uses thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2017-10-17 | — | — | US | disclosed |
| WO-2014145887-A1 | BENZIMIDAZOLE DERIVATIVES AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2014-09-18 | — | — | WO | disclosed |