Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 12/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 15/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16083175 | 0.90 | HDAC2 (0.64) | HDAC2HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL3551291 | 0.89 | HDAC2 (0.63) | HDAC2HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL8231187 | 0.89 | HDAC2 (0.60) | HDAC2HDAC1HDAC3MAPK1KDM1A | |
| SCHEMBL16083086 | 0.89 | HDAC2 (0.65) | HDAC2HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL3558649 | 0.88 | HDAC2 (0.61) | HDAC2HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL16083165 | 0.87 | HDAC2 (0.66) | HDAC2HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL3551917 | 0.87 | HDAC2 (0.59) | HDAC2HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL20194276 | 0.86 | HDAC2 (0.67) | HDAC2HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL16083168 | 0.86 | HDAC2 (0.62) | HDAC2HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL3551358 | 0.86 | HDAC2 (0.59) | HDAC2HDAC1HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10428028-B2 | HDAC inhibitors | BIOMARIN PHARMACEUTICAL INC. (US) | 2019-10-01 | — | — | US | disclosed |
| US-10029988-B2 | HDAC inhibitors | BIOMARIN PHARMACEUTICAL INC. (US) | 2018-07-24 | — | — | US | disclosed |
| US-10029988-B2 | HDAC inhibitors | BIOMARIN PHARMACEUTICAL INC. (US) | 2018-07-24 | — | — | US | disclosed |
| EP-2970139-B1 | HDAC INHIBITORS | BIOMARIN PHARM INC (US) | 2018-05-30 | — | — | EP | disclosed |
| US-20160031823-A1 | HDAC INHIBITORS | BIOMARIN PHARMACEUTICAL INC. | 2016-02-04 | — | — | US | disclosed |
| US-20160031823-A1 | HDAC INHIBITORS | BIOMARIN PHARMACEUTICAL INC. | 2016-02-04 | — | — | US | disclosed |
| WO-2014143666-A1 | HDAC INHIBITORS | BIOMARIN PHARMACEUTICAL INC. (US) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10029988-B2 | HDAC inhibitors | HDAC1, HDAC2, HDAC11 | HDAC2 2/4885HDAC1 1/4885HDAC3 4/4885 |
| US-10428028-B2 | HDAC inhibitors | HDAC1, HDAC2, HDAC11 | HDAC2 2/4885HDAC1 1/4885HDAC3 4/4885 |
| US-20160031823-A1 | HDAC INHIBITORS | HDAC1, HDAC2, HDAC11 | HDAC2 2/4885HDAC1 1/4885HDAC3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.