Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PKLR | P30613 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | LIPE | Q05469 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16049616 | 0.84 | USP2 (0.46) | TACR1USP2SMN1; SMN2PKLRHPGD | |
| SCHEMBL849402 | 0.80 | USP2 (0.49) | TACR1USP2SMN1; SMN2MAPTHPGD | |
| SCHEMBL15742971 | 0.80 | USP2 (0.49) | TACR1USP2SMN1; SMN2HPGDEPHX2 | |
| SCHEMBL2945193 | 0.79 | USP2 (0.50) | TACR1USP2SMN1; SMN2HPGDEPHX2 | |
| SCHEMBL2349423 | 0.79 | USP2 (0.50) | TACR1USP2SMN1; SMN2HPGDEPHX2 | |
| SCHEMBL16049599 | 0.78 | USP2 (0.44) | TACR1USP2SMN1; SMN2PKLRMAPT | |
| SCHEMBL1934149 | 0.78 | USP2 (0.41) | TACR1USP2SMN1; SMN2HPGDEPHX2 | |
| SCHEMBL26665526 | 0.78 | USP2 (0.46) | TACR1USP2SMN1; SMN2HPGDEPHX2 | |
| SCHEMBL154164 | 0.77 | USP2 (0.49) | USP2SMN1; SMN2HPGDEPHX2DPP4 | |
| SCHEMBL2525447 | 0.77 | USP2 (0.49) | TACR1USP2SMN1; SMN2HPGDEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970189-B1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS INC (US) | 2020-05-06 | — | — | EP | disclosed |
| WO-2014139325-A1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |