Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.84 |
| ▸ | KDR | P35968 | 14/20 | 0.84 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.84 |
| ▸ | FLT1 | P17948 | 12/20 | 0.84 |
| ▸ | FLT4 | P35916 | 12/20 | 0.84 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.84 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.84 |
| ▸ | RET | P07949 | 3/20 | 0.84 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.84 |
| ▸ | TEK | Q02763 | 2/20 | 0.84 |
| ▸ | KIF5B | P33176 | 2/20 | 0.84 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.84 |
| ▸ | PLK4 | O00444 | 1/20 | 0.84 |
| ▸ | CIT | O14578 | 1/20 | 0.84 |
| ▸ | GAK | O14976 | 1/20 | 0.84 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.84 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.84 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.84 |
| ▸ | STK10 | O94804 | 1/20 | 0.84 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1657315 | 0.92 | EGFR (0.83) | EGFRKDRFGFR1FLT1FLT4 | |
| Vandetanib SCHEMBL9044 | 0.91 | EGFR (1.00) | EGFRKDRFGFR1FLT1FLT4 | |
| Vandetanib SCHEMBL28224661 | 0.91 | EGFR (1.00) | EGFRKDRFGFR1FLT1FLT4 | |
| Vandetanib SCHEMBL29352879 | 0.91 | EGFR (1.00) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL20343335 | 0.91 | EGFR (0.80) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL26359052 | 0.91 | EGFR (0.85) | EGFRKDRFGFR1FLT1FLT4 | |
| Vandetanib SCHEMBL4637084 | 0.91 | EGFR (0.98) | EGFRKDRFGFR1FLT1FLT4 | |
| Vandetanib SCHEMBL1614458 | 0.91 | EGFR (1.00) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL23965916 | 0.88 | EGFR (0.80) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL18627731 | 0.88 | EGFR (0.80) | EGFRKDRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014141057-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | KANDULA MAHESH (IN) | 2014-09-18 | — | — | WO | disclosed |