SCHEMBL16085449

SCHEMBL16085449

Cc1cccnc1C(=O)N1CCc2cc(-c3nc(NC(=O)Cc4ccc5c(c4)OCO5)sc3C)ccc21

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 7/20 0.81
POLB P06746 2/20 0.81
MAFG O15525 1/20 0.81
HPGD P15428 1/20 0.81
NFE2L2 Q16236 1/20 0.81
L3MBTL1 Q9Y468 1/20 0.81
LMNA P02545 5/20 0.74
HTT P42858 3/20 0.74
ALDH1A1 P00352 4/20 0.74
NT5E P21589 1/20 0.50
MEN1 O00255 3/20 0.49
KMT2A Q03164 3/20 0.49
MAPT P10636 2/20 0.47
GAA P10253 1/20 0.47
NPSR1 Q6W5P4 1/20 0.45
USP2 O75604 1/20 0.44
ROCK2 O75116 1/20 0.43
NR2F2 P24468 1/20 0.43
RAB9A P51151 1/20 0.43
CFTR P13569 6/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16085467 0.90 SMN1; SMN2 (0.83) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL30440736 0.89 SMN1; SMN2 (1.00) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL16085609 0.89 SMN1; SMN2 (1.00) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL29419037 0.89 SMN1; SMN2 (1.00) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL16085413 0.88 SMN1; SMN2 (0.86) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL16085600 0.87 SMN1; SMN2 (0.76) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL16085468 0.87 SMN1; SMN2 (0.80) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL16085574 0.86 SMN1; SMN2 (0.77) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL16085469 0.86 SMN1; SMN2 (0.89) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL16085145 0.86 SMN1; SMN2 (0.83) SMN1; SMN2POLBMAFGHPGDNFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014145642-A9 NRF2 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY THE JOHNS HOPKINS UNIVERSITY (US) 2014-11-13 WO disclosed
WO-2014145642-A2 NRF2 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY THE JOHNS HOPKINS UNIVERSITY (US) 2014-09-18 WO disclosed