Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.48 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 9/20 | 0.40 |
| ▸ | EGFR | P00533 | 7/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16086932 | 0.94 | BRAF (0.56) | BRAFTNNI3KSRCMKNK2EGFR | |
| SCHEMBL1805579 | 0.84 | BRAF (0.53) | BRAFTNNI3KSRCMKNK2EGFR | |
| SCHEMBL16087008 | 0.82 | BRAF (0.56) | BRAFTNNI3KMKNK2EGFRMKNK1 | |
| Trifluoroacetic Acid SCHEMBL12003611 | 0.82 | BRAF (0.59) | BRAFTNNI3KSRCMKNK2EGFR | |
| SCHEMBL16086953 | 0.80 | BRAF (0.53) | BRAFTNNI3KSRCMKNK2EGFR | |
| SCHEMBL6912956 | 0.79 | BRAF (0.61) | BRAFTNNI3KSRCMKNK2EGFR | |
| Trifluoroacetic Acid SCHEMBL12004218 | 0.76 | TNNI3K (0.67) | BRAFTNNI3KSRCMKNK2EGFR | |
| SCHEMBL6910970 | 0.75 | BRAF (0.72) | BRAFTNNI3KSRCEGFR | |
| SCHEMBL6911924 | 0.75 | TNNI3K (0.73) | BRAFTNNI3KSRCMKNK2EGFR | |
| SCHEMBL14322805 | 0.75 | TNNI3K (0.49) | TNNI3KEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501233-B1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2014-09-24 | — | — | EP | disclosed |