Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARK3 | P27448 | 12/20 | 0.70 |
| ▸ | KDR | P35968 | 8/20 | 0.54 |
| ▸ | FLT1 | P17948 | 3/20 | 0.49 |
| ▸ | FLT4 | P35916 | 3/20 | 0.49 |
| ▸ | ULK1 | O75385 | 1/20 | 0.49 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.49 |
| ▸ | SGK1 | O00141 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3763532 | 0.99 | MARK3 (0.69) | MARK3KDRFLT1FLT4ULK1 | |
| SCHEMBL3772483 | 0.90 | MARK3 (0.69) | MARK3KDRFLT1FLT4ULK1 | |
| SCHEMBL5414309 | 0.88 | KDR (0.60) | MARK3KDRFLT1FLT4ULK1 | |
| SCHEMBL3762774 | 0.86 | MARK3 (0.72) | MARK3KDRULK1ULK2MKNK2 | |
| SCHEMBL3772433 | 0.85 | MARK3 (0.70) | MARK3KDRULK1ULK2MKNK2 | |
| SCHEMBL3766784 | 0.84 | MARK3 (0.69) | MARK3KDRULK1ULK2MKNK2 | |
| SCHEMBL3769325 | 0.83 | MARK3 (0.70) | MARK3KDRULK1ULK2MKNK2 | |
| SCHEMBL3766751 | 0.83 | MARK3 (0.70) | MARK3KDRULK1ULK2MKNK2 | |
| SCHEMBL3764916 | 0.83 | MARK3 (0.68) | MARK3KDRULK1ULK2MKNK2 | |
| SCHEMBL3769144 | 0.83 | MARK3 (0.68) | MARK3KDRULK1ULK2MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178375-B1 | PYRAZOLOÝ1,5-A¨PYRIMIDINE DERIVATIVES | MERCK SHARP & DOHME (US) | 2014-09-24 | — | — | EP | disclosed |