Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 9/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17547856 | 0.90 | KDM5A (0.46) | KDM5AKDM5BS1PR1GRM5KDM4D | |
| SCHEMBL16092232 | 0.90 | KDM5A (0.57) | KDM5AKDM5BADORA1KDM5CKDM4C | |
| SCHEMBL16092262 | 0.89 | KDM5A (0.47) | KDM5AKDM5BKDM5CKDM4C | |
| SCHEMBL16092096 | 0.86 | KDM5A (0.47) | KDM5AKDM5BADORA1KDM5CKDM4C | |
| SCHEMBL16092231 | 0.85 | KDM5A (0.47) | KDM5AKDM5BKDM5CKDM4C | |
| SCHEMBL17547857 | 0.84 | KDM5B (0.48) | KDM5AKDM5BKMT2AKDM5CKDM4C | |
| SCHEMBL16092474 | 0.81 | GRM5 (0.44) | KDM5AKDM5BGRM5ADORA1KDM5C | |
| SCHEMBL16092556 | 0.81 | KDM5B (0.49) | KDM5AKDM5BGRM5KDM4DKDM5C | |
| SCHEMBL16092560 | 0.80 | KDM5A (0.39) | KDM5AKDM5BKDM4DKDM5CKDM4C | |
| SCHEMBL16092317 | 0.80 | KDM5A (0.48) | KDM5AKDM5BKDM4DKDM5CKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015135094-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2015-09-17 | — | — | WO | disclosed |
| WO-2014139326-A1 | PYRAZOLO COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2014-09-18 | — | — | WO | disclosed |