Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 9/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | FASN | P49327 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16092243 | 0.89 | KDM5A (0.43) | KDM5AKDM5BKDM6BKDM5CKDM5D | |
| SCHEMBL16092493 | 0.89 | KDM5B (0.48) | KDM5AKDM5BKDM6BKDM5CKDM5D | |
| SCHEMBL17085740 | 0.88 | KDM5A (0.39) | KDM5AKDM5BKDM6BKDM5CKDM5D | |
| SCHEMBL16050761 | 0.88 | KDM5A (0.41) | KDM5AKDM5BKDM6BKDM5CKDM5D | |
| SCHEMBL16092255 | 0.88 | KDM5B (0.42) | KDM5AKDM5BKDM6BKDM5CKDM5D | |
| SCHEMBL16092249 | 0.88 | KDM5A (0.47) | KDM5AKDM5BKDM6BKDM5CKDM5D | |
| SCHEMBL16092448 | 0.88 | KDM5B (0.46) | KDM5AKDM5BKDM6BKDM5CKDM5D | |
| SCHEMBL16092258 | 0.87 | KDM5B (0.46) | KDM5AKDM5BKDM6BKDM5CKDM5D | |
| SCHEMBL16092248 | 0.87 | KDM4E (0.46) | KDM5AKDM5BKDM6BKDM5CKDM5D | |
| SCHEMBL16092254 | 0.86 | KDM5A (0.55) | KDM5AKDM5BKDM6BKDM5CKDM5D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014139326-A1 | PYRAZOLO COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2014-09-18 | — | — | WO | disclosed |