Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAT | P00750 | 3/20 | 0.42 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 6/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16092343 | 0.84 | PLAT (0.42) | PLATKDM5AKDM5BKDM4EALDH1A1 | |
| SCHEMBL16092414 | 0.81 | PLAT (0.45) | PLATKDM5AKDM4EALDH1A1 | |
| SCHEMBL16092344 | 0.79 | PLAT (0.41) | PLATKDM5ARETKDM5BKDM4E | |
| SCHEMBL16092319 | 0.79 | PLAT (0.42) | PLATKDM5ARETKDM4EALDH1A1 | |
| SCHEMBL17547872 | 0.79 | PLAT (0.43) | PLATKDM5AKDM5BKDM4EALDH1A1 | |
| SCHEMBL16092368 | 0.78 | KDM5B (0.47) | PLATKDM5ARETKDM5BKDM4E | |
| SCHEMBL16092240 | 0.78 | PLAT (0.41) | PLATKDM5AKDM5BKDM4EALDH1A1 | |
| SCHEMBL16050683 | 0.77 | KDM5A (0.38) | PLATKDM5AKDM5B | |
| SCHEMBL17547841 | 0.77 | PLAT (0.41) | PLATKDM5AKDM5B | |
| SCHEMBL20426060 | 0.77 | PLAT (0.45) | PLATKDM5AKDM5BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015135094-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2015-09-17 | — | — | WO | disclosed |
| WO-2014139326-A1 | PYRAZOLO COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2014-09-18 | — | — | WO | disclosed |