Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 7/20 | 0.35 |
| ▸ | CA9 | Q16790 | 7/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.35 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.35 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 5/20 | 0.35 |
| ▸ | KDM5A | P29375 | 5/20 | 0.34 |
| ▸ | KDM5C | P41229 | 2/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.34 |
| ▸ | P4HB | P07237 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16092320 | 0.87 | KDM5A (0.36) | KDM5AKDM5CKDM5BKDM4D | |
| SCHEMBL16092530 | 0.85 | GCK (0.38) | ADORA2BKDM5AKDM5CKDM5BKDM4D | |
| SCHEMBL16092242 | 0.80 | KDM5B (0.44) | KDM5AKDM5CKDM5BKDM4D | |
| SCHEMBL16092317 | 0.80 | KDM5A (0.48) | KDM5AKDM5CKDM5BKDM4D | |
| SCHEMBL16092436 | 0.79 | KDM5B (0.38) | KDM5AKDM5CKDM5BKDM4D | |
| SCHEMBL16092238 | 0.79 | CSNK2A1 (0.39) | KDM5AKDM5CKDM5BKDM4D | |
| SCHEMBL16092513 | 0.79 | KDM5A (0.46) | KDM5AKDM5CKDM5BKDM4DALDH1A1 | |
| SCHEMBL16092523 | 0.79 | KDM5A (0.49) | KDM5AKDM5CKDM5BKDM4DALDH1A1 | |
| SCHEMBL16092249 | 0.79 | KDM5A (0.47) | KDM5AKDM5CKDM5BKDM4DALDH1A1 | |
| SCHEMBL17547839 | 0.78 | KDM5B (0.44) | KDM5AKDM5CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015135094-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2015-09-17 | — | — | WO | disclosed |
| WO-2014139326-A1 | PYRAZOLO COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2014-09-18 | — | — | WO | disclosed |