Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 20/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16093124 | 0.85 | ATR (0.66) | ATR | |
| SCHEMBL16070011 | 0.85 | ATR (1.00) | ATR | |
| SCHEMBL3059569 | 0.81 | ATR (0.82) | ATR | |
| SCHEMBL2511199 | 0.80 | ATR (0.84) | ATR | |
| SCHEMBL2513711 | 0.80 | ATR (1.00) | ATR | |
| SCHEMBL13138014 | 0.80 | ATR (0.84) | ATR | |
| SCHEMBL3052735 | 0.80 | ATR (0.84) | ATR | |
| SCHEMBL2482502 | 0.80 | ATR (1.00) | ATR | |
| SCHEMBL13138106 | 0.79 | ATR (1.00) | ATR | |
| SCHEMBL13137961 | 0.79 | ATR (1.00) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841308-B2 | Pyrazin-2-amines useful as inhibitors of ATR kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-09-23 | — | — | US | disclosed |
| US-8841308-B2 | Pyrazin-2-amines useful as inhibitors of ATR kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-09-23 | — | — | US | disclosed |