Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 9/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19941047 | 1.00 | GRM2 (0.47) | GRM2MAOAF10 | |
| SCHEMBL19938072 | 0.89 | GRM2 (0.51) | GRM2 | |
| SCHEMBL12939662 | 0.86 | GRM2 (0.46) | GRM2F10 | |
| SCHEMBL14270038 | 0.86 | GRM2 (0.46) | GRM2F10 | |
| SCHEMBL9969453 | 0.86 | GRM2 (0.46) | GRM2F10 | |
| SCHEMBL14270222 | 0.84 | GRM2 (0.43) | GRM2F10 | |
| SCHEMBL16788839 | 0.84 | GRM2 (0.43) | GRM2F10 | |
| SCHEMBL16092980 | 0.84 | GRM2 (0.43) | GRM2F10 | |
| SCHEMBL4952331 | 0.83 | GRM2 (0.49) | GRM2 | |
| SCHEMBL3328310 | 0.83 | GRM2 (0.65) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841263-B2 | Macrocyclic compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2014-09-23 | — | — | US | disclosed |