Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17418127 | 1.00 | SCN9A (0.46) | SCN9ASCN5AS1PR1CACNA1CCXCR3 | |
| SCHEMBL16119827 | 1.00 | SCN9A (0.46) | SCN9ASCN5AS1PR1CACNA1CCXCR3 | |
| SCHEMBL17418112 | 0.75 | SCN9A (0.49) | SCN9ASCN5AS1PR1CACNA1CHDAC6 | |
| SCHEMBL17418072 | 0.75 | SCN9A (0.49) | SCN9ASCN5AS1PR1CACNA1CHDAC6 | |
| SCHEMBL17418081 | 0.74 | SCN9A (0.54) | SCN9ASCN5AS1PR1CACNA1CALOX15 | |
| SCHEMBL16119833 | 0.74 | SCN9A (0.54) | SCN9ASCN5AS1PR1CACNA1CALOX15 | |
| SCHEMBL17418003 | 0.71 | SCN9A (0.41) | SCN9ASCN5AS1PR1CACNA1CCXCR3 | |
| SCHEMBL17418002 | 0.71 | SCN9A (0.41) | SCN9ASCN5AS1PR1CACNA1CCXCR3 | |
| SCHEMBL17433251 | 0.71 | SCN9A (0.45) | SCN9ACNR1CNR2 | |
| SCHEMBL18400103 | 0.71 | CNR2 (0.31) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968280-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014153037-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |