Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 8/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16093771 | 0.96 | KDM4E (0.52) | MAPTMEN1KMT2AKDM4ESHMT2 | |
| SCHEMBL16122157 | 0.90 | MEN1 (0.48) | MAPTMEN1KMT2AKDM4ESHMT2 | |
| SCHEMBL30642284 | 0.89 | MAPT (0.47) | MAPTMEN1KMT2AKDM4ESHMT2 | |
| SCHEMBL16122156 | 0.89 | MAPT (0.47) | MAPTMEN1KMT2AKDM4ESHMT2 | |
| SCHEMBL16122866 | 0.86 | KDM4E (0.49) | MAPTMEN1KMT2AKDM4ESHMT2 | |
| SCHEMBL16122865 | 0.85 | MAPT (0.48) | MAPTMEN1KMT2AKDM4ESHMT2 | |
| SCHEMBL30642313 | 0.85 | MAPT (0.48) | MAPTMEN1KMT2AKDM4ESHMT2 | |
| SCHEMBL16093632 | 0.85 | MAPT (0.53) | MAPTMEN1KMT2AKDM4ESHMT2 | |
| SCHEMBL16098788 | 0.85 | MAPT (0.53) | MAPTMEN1KMT2AKDM4ESHMT2 | |
| SCHEMBL16093839 | 0.84 | MAPT (0.57) | MAPTMEN1KMT2AKDM4ESHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3401314-A1 | COVALENT INHIBITORS OF KRAS G12C | Araxes Pharma LLC (US) | 2018-11-14 | — | — | EP | disclosed |
| EP-2970121-A1 | COVALENT INHIBITORS OF KRAS G12C | Araxes Pharma LLC (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014152588-A1 | COVALENT INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC (US) | 2014-09-25 | — | — | WO | disclosed |