Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARK3 | P27448 | 18/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.72 |
| ▸ | SGK1 | O00141 | 2/20 | 0.72 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.72 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.72 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.72 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.72 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.72 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.72 |
| ▸ | JAK2 | O60674 | 2/20 | 0.72 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.72 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.72 |
| ▸ | EGFR | P00533 | 2/20 | 0.72 |
| ▸ | RAF1 | P04049 | 2/20 | 0.72 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.72 |
| ▸ | LCK | P06239 | 2/20 | 0.72 |
| ▸ | CSF1R | P07333 | 2/20 | 0.72 |
| ▸ | MET | P08581 | 2/20 | 0.72 |
| ▸ | HCK | P08631 | 2/20 | 0.72 |
| ▸ | KIT | P10721 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3764938 | 0.87 | MARK3 (1.00) | MARK3MAPK1SGK1PIK3CDCHEK1 | |
| SCHEMBL3763591 | 0.86 | MARK3 (0.74) | MARK3MAPK1SGK1PIK3CDCHEK1 | |
| SCHEMBL3756835 | 0.86 | MARK3 (0.74) | MARK3MAPK1SGK1PIK3CDCHEK1 | |
| SCHEMBL3764980 | 0.85 | MARK3 (0.82) | MARK3MAPK1SGK1PIK3CDCHEK1 | |
| SCHEMBL3758754 | 0.85 | MARK3 (0.82) | MARK3MAPK1SGK1PIK3CDCHEK1 | |
| SCHEMBL3761594 | 0.84 | MARK3 (0.83) | MARK3MAPK1SGK1PIK3CDCHEK1 | |
| SCHEMBL3768845 | 0.84 | MARK3 (1.00) | MARK3MAPK1SGK1PIK3CDCHEK1 | |
| SCHEMBL3762598 | 0.84 | MARK3 (0.83) | MARK3MAPK1SGK1PIK3CDCHEK1 | |
| SCHEMBL3768919 | 0.84 | MARK3 (0.79) | MARK3MAPK1SGK1PIK3CDCHEK1 | |
| SCHEMBL3765875 | 0.82 | MARK3 (0.83) | MARK3MAPK1SGK1PIK3CDCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178375-B1 | PYRAZOLOÝ1,5-A¨PYRIMIDINE DERIVATIVES | MERCK SHARP & DOHME (US) | 2014-09-24 | — | — | EP | disclosed |