Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | XDH | P47989 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 2/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | AKT2 | P31751 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16111375 | 1.00 | DRD3 (0.49) | DRD3MAOAMAOBPIM1PIM2 | |
| SCHEMBL17451496 | 1.00 | DRD3 (0.49) | DRD3MAOAMAOBPIM1PIM2 | |
| SCHEMBL17451495 | 0.92 | KMT2A (0.56) | DRD3MAOAMAOBPIM1PIM2 | |
| SCHEMBL11504421 | 0.81 | MAOB (0.58) | MAOAMAOBPIM1PIM2EGFR | |
| SCHEMBL11504420 | 0.81 | MAOB (0.58) | MAOAMAOBPIM1PIM2EGFR | |
| SCHEMBL11504407 | 0.81 | CYP1A2 (0.65) | MAOAMAOBPIM1PIM2MAPT | |
| SCHEMBL11504406 | 0.81 | CYP1A2 (0.65) | MAOAMAOBPIM1PIM2MAPT | |
| SCHEMBL8116310 | 0.80 | CYP1A2 (0.67) | MAOAMAOBPIM1PIM2MAPT | |
| SCHEMBL11504566 | 0.80 | CYP1A2 (0.67) | MAOAMAOBPIM1PIM2MAPT | |
| SCHEMBL11504568 | 0.80 | CYP1A2 (0.67) | MAOAMAOBPIM1PIM2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10208012-B2 | Compounds for treating inflammatory and hyperproliferative diseases | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-02-19 | — | — | US | disclosed |
| US-20160016931-A1 | COMPOUNDS FOR TREATING INFLAMMATORY AND HYPERPROLIFERATIVE DISEASES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2016-01-21 | — | — | US | disclosed |
| WO-2014160339-A1 | COMPOUNDS FOR TREATING INFLAMMATORY AND HYPERPROLIFERATIVE DISEASES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10208012-B2 | Compounds for treating inflammatory and hyperproliferative diseases | NFKBIA, PCNA, MYC | DRD3 4641/4885MAOA 4427/4885MAOB 4234/4885 |
| US-20160016931-A1 | COMPOUNDS FOR TREATING INFLAMMATORY AND HYPERPROLIFERATIVE DISEASES | NFKBIA, PCNA, MYC | DRD3 4641/4885MAOA 4427/4885MAOB 4234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.