Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16112031 | 0.90 | KDM1A (0.51) | KDM1AGAAPKMEPHX2HDAC4 | |
| SCHEMBL26857799 | 0.83 | AKR1C3 (0.51) | SLC6A4SLC6A2SLC6A3FFAR4EPHX2 | |
| SCHEMBL26857966 | 0.81 | SLC6A2 (0.46) | SLC6A4SLC6A2SLC6A3FFAR4EPHX2 | |
| SCHEMBL5623359 | 0.81 | HRH1 (0.41) | KDM1ASLC6A4SLC6A2SLC6A3EPHX2 | |
| SCHEMBL10188583 | 0.78 | PARP10 (0.44) | FFAR4PKMEPHX2 | |
| SCHEMBL1749499 | 0.76 | ACSL1 (0.56) | SLC6A4SLC6A2SLC6A3EPHX2HRH1 | |
| SCHEMBL2475964 | 0.76 | GAA (0.47) | SLC6A4SLC6A2SLC6A3FFAR4GAA | |
| SCHEMBL2476884 | 0.76 | GAA (0.47) | SLC6A4SLC6A2SLC6A3FFAR4GAA | |
| SCHEMBL2475966 | 0.76 | GAA (0.47) | SLC6A4SLC6A2SLC6A3FFAR4GAA | |
| SCHEMBL6932018 | 0.75 | FFAR4 (0.49) | SLC6A4SLC6A2SLC6A3FFAR4PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968233-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI Foundation, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014159224-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. (US) | 2014-10-02 | — | — | WO | disclosed |