Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 8/20 | 0.74 |
| ▸ | CDK8 | P49336 | 8/20 | 0.74 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16116177 | 0.85 | CCNC (0.55) | CCNCCDK8GPR35 | |
| SCHEMBL16116379 | 0.85 | CCNC (1.00) | CCNCCDK8IMPDH2CSNK1A1CSNK1D | |
| SCHEMBL31189709 | 0.83 | CCNC (0.68) | CCNCCDK8IMPDH2CSNK1A1CSNK1D | |
| SCHEMBL16115235 | 0.81 | CCNC (0.77) | CCNCCDK8DYRK1ANFATC1GSK3B | |
| SCHEMBL16115990 | 0.80 | CCNC (0.65) | CCNCCDK8IMPDH2MAPK1HSD17B10 | |
| SCHEMBL16116227 | 0.80 | CCNC (0.77) | CCNCCDK8IMPDH2DYRK1AMAPK1 | |
| SCHEMBL16115256 | 0.80 | CCNC (0.76) | CCNCCDK8IMPDH2DYRK1AMAPK1 | |
| SCHEMBL26113876 | 0.79 | CCNC (0.63) | CCNCCDK8IMPDH2CSNK1A1CSNK1D | |
| SCHEMBL16116161 | 0.77 | CCNC (0.57) | CCNCCDK8DYRK1AGPR35NFATC1 | |
| SCHEMBL16116231 | 0.76 | CCNC (0.76) | CCNCCDK8IMPDH2DYRK1AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014154723-A1 | NOVEL PYRROLE DERIVATIVES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2014-10-02 | — | — | WO | disclosed |
| WO-2014154723-A1 | NOVEL PYRROLE DERIVATIVES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2014-10-02 | — | — | WO | disclosed |