Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 15/20 | 0.72 |
| ▸ | EED | O75530 | 5/20 | 0.72 |
| ▸ | SUZ12 | Q15022 | 5/20 | 0.72 |
| ▸ | EZH1 | Q92800 | 8/20 | 0.59 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.59 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.59 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16116153 | 0.93 | EZH2 (0.63) | EZH2EEDSUZ12EZH1RBBP4 | |
| SCHEMBL16115003 | 0.93 | EZH2 (0.66) | EZH2EEDSUZ12EZH1RBBP4 | |
| SCHEMBL16115764 | 0.92 | EZH2 (0.69) | EZH2EEDSUZ12EZH1RBBP4 | |
| SCHEMBL16115079 | 0.92 | EZH1 (0.66) | EZH2EEDSUZ12EZH1RBBP4 | |
| SCHEMBL16116124 | 0.91 | EZH2 (0.68) | EZH2EEDSUZ12EZH1RBBP4 | |
| SCHEMBL16115907 | 0.91 | EZH2 (0.69) | EZH2EEDSUZ12EZH1RBBP4 | |
| SCHEMBL16116259 | 0.91 | EZH2 (0.71) | EZH2EEDSUZ12EZH1RBBP4 | |
| SCHEMBL16114921 | 0.85 | EZH2 (0.64) | EZH2EEDSUZ12EZH1RBBP4 | |
| SCHEMBL16115525 | 0.85 | EZH1 (0.64) | EZH2EEDSUZ12EZH1RBBP4 | |
| SCHEMBL16115555 | 0.84 | EZH2 (0.67) | EZH2EEDSUZ12EZH1RBBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014155301-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS INHIBITORS OF EZH2 | Piramal Enterprises Limited (IN) | 2014-10-02 | — | — | WO | claimed |
| WO-2014155301-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS INHIBITORS OF EZH2 | Piramal Enterprises Limited (IN) | 2014-10-02 | — | — | WO | disclosed |