Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.60 |
| ▸ | BRD4 | O60885 | 1/20 | 0.60 |
| ▸ | EED | O75530 | 2/20 | 0.50 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.50 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.50 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.50 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.50 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16116298 | 0.92 | EZH2 (0.60) | EZH2BRD4EEDSUZ12RBBP4 | |
| SCHEMBL16115715 | 0.85 | EZH2 (0.60) | EZH2BRD4EEDSUZ12RBBP4 | |
| SCHEMBL16116053 | 0.83 | EZH2 (0.53) | EZH2EEDSUZ12EZH1 | |
| SCHEMBL2594802 | 0.81 | EZH2 (0.72) | EZH2EEDSUZ12RBBP4RBBP7 | |
| SCHEMBL16115846 | 0.80 | GRIN2B (0.43) | BRD4 | |
| SCHEMBL16116111 | 0.79 | GRIN2B (0.43) | BRD4 | |
| SCHEMBL16115918 | 0.78 | EZH2 (0.72) | EZH2EEDSUZ12RBBP4RBBP7 | |
| SCHEMBL19620972 | 0.78 | EZH2 (0.72) | EZH2EEDSUZ12RBBP4RBBP7 | |
| SCHEMBL16115816 | 0.77 | EZH2 (0.70) | EZH2EEDSUZ12RBBP4RBBP7 | |
| SCHEMBL2595894 | 0.76 | EZH2 (0.63) | EZH2EEDSUZ12RBBP4RBBP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014155301-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS INHIBITORS OF EZH2 | Piramal Enterprises Limited (IN) | 2014-10-02 | — | — | WO | disclosed |