Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.64 |
| ▸ | EZH1 | Q92800 | 4/20 | 0.61 |
| ▸ | EED | O75530 | 3/20 | 0.59 |
| ▸ | SUZ12 | Q15022 | 3/20 | 0.59 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.59 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16115871 | 0.90 | EZH2 (0.57) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL14730095 | 0.88 | EZH2 (0.71) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16116018 | 0.85 | EZH2 (0.57) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16115294 | 0.83 | EZH2 (0.58) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16116270 | 0.83 | EZH2 (0.68) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16115913 | 0.82 | EZH2 (0.55) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16114975 | 0.82 | EZH2 (0.70) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16115548 | 0.81 | EZH2 (0.76) | EZH2EZH1EEDSUZ12RBBP4 | |
| Hydrochloric Acid SCHEMBL16116117 | 0.81 | EZH2 (0.75) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16115786 | 0.80 | EZH2 (0.65) | EZH2EZH1EEDSUZ12RBBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014155301-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS INHIBITORS OF EZH2 | Piramal Enterprises Limited (IN) | 2014-10-02 | — | — | WO | claimed |
| WO-2014155301-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS INHIBITORS OF EZH2 | Piramal Enterprises Limited (IN) | 2014-10-02 | — | — | WO | disclosed |