SCHEMBL1612142

SCHEMBL1612142

Cc1ccc2c(c1)c1ccccc1n2-c1cccnc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.49
METAP2 P50579 3/20 0.49
MDM2 Q00987 1/20 0.48
ALOX12 P18054 1/20 0.47
KDM4E B2RXH2 1/20 0.44
ATM Q13315 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
GSR P00390 1/20 0.41
MAP2K4 P45985 1/20 0.40
CYP11B2 P19099 1/20 0.40
GFER P55789 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
CYP2A6 P11509 2/20 0.40
CYP2E1 P05181 1/20 0.40
CYP3A4 P08684 1/20 0.40
MAT2A P31153 2/20 0.39
PSD A5PKW4 1/20 0.39
HRH1 P35367 1/20 0.39
HTR6 P50406 1/20 0.39
MEN1 O00255 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10206185 0.90 CYP1A2 (0.46) CYP1A2METAP2MDM2ALOX12KDM4E
SCHEMBL15153878 0.86 CYP1A2 (0.52) CYP1A2METAP2MDM2ALOX12KDM4E
SCHEMBL10449450 0.86 CYP1A2 (0.52) CYP1A2METAP2MDM2ALOX12KDM4E
SCHEMBL16484319 0.86 KDM4E (0.59) CYP1A2METAP2MDM2ALOX12KDM4E
SCHEMBL17228027 0.85 CYP1A2 (0.51) CYP1A2METAP2MDM2ALOX12KDM4E
SCHEMBL1611068 0.85 CYP1A2 (0.46) CYP1A2METAP2MDM2ALOX12L3MBTL1
SCHEMBL10206159 0.84 CYP1A2 (0.41) CYP1A2METAP2MDM2ALOX12KDM4E
SCHEMBL30118222 0.83 MDM2 (0.47) CYP1A2METAP2MDM2ALOX12KDM4E
SCHEMBL1611168 0.83 KDM4E (0.48) KDM4EATML3MBTL1GSRNPSR1
SCHEMBL15749894 0.83 CYP2A6 (0.48) MDM2KDM4EMAP2K4CYP11B2NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9090819-B2 Organic electroluminescent element, display device, illuminating device and condensed polycyclic heterocyclic compound Konica Minolta, Inc. (JP) 2015-07-28 US disclosed
US-9090819-B2 Organic electroluminescent element, display device, illuminating device and condensed polycyclic heterocyclic compound Konica Minolta, Inc. (JP) 2015-07-28 US disclosed
US-20120085997-A1 ORGANIC ELECTROLUMINESCENT ELEMENT, DISPLAY DEVICE, ILLUMINATING DEVICE AND CONDENSED POLYCYCLIC HETEROCYCLIC COMPOUND KONICA MINOLTA HOLDINGS, INC. (JP) 2012-04-12 US disclosed
US-20120085997-A1 ORGANIC ELECTROLUMINESCENT ELEMENT, DISPLAY DEVICE, ILLUMINATING DEVICE AND CONDENSED POLYCYCLIC HETEROCYCLIC COMPOUND KONICA MINOLTA HOLDINGS, INC. (JP) 2012-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120085997-A1 ORGANIC ELECTROLUMINESCENT ELEMENT, DISPLAY DEVICE, ILLUMINATING DEVICE AND CONDENSED POLYCYCLIC HETEROCYCLIC COMPOUND CCNE2, C1S, SCO2 CYP1A2 643/4885METAP2 2887/4885MDM2 1888/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.