⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1252958 | 0.69 | — | — | |
| SCHEMBL50016 | 0.69 | — | — | |
| SCHEMBL30233879 | 0.67 | — | — | |
| SCHEMBL24072198 | 0.67 | — | — | |
| SCHEMBL3381448 | 0.64 | — | — | |
| SCHEMBL16860020 | 0.64 | — | — | |
| SCHEMBL6170826 | 0.64 | — | — | |
| SCHEMBL4067361 | 0.63 | KDM4E (0.33) | — | |
| SCHEMBL2210359 | 0.62 | — | — | |
| Hydrochloric Acid SCHEMBL9080539 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10273264-B2 | Cortistatin analogues and syntheses and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-04-30 | — | — | US | disclosed |
| US-10273240-B2 | Cortistatin analogues, syntheses, and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-04-30 | — | — | US | disclosed |
| US-20180135134-A1 | TARGETED SELECTION OF PATIENTS FOR TREATMENT WITH CORTISTATIN DERIVATIVES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-05-17 | — | — | US | disclosed |
| US-20180134725-A1 | CORTISTATIN ANALOGUES, SYNTHESES, AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-05-17 | — | — | US | disclosed |
| US-20180118778-A1 | CORTISTATIN ANALOGUES AND SYNTHESES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-05-03 | — | — | US | disclosed |
| CN-107847763-A | Targeted selection of patients eligible for treatment with cortistatin derivatives | 哈佛学院院长等 | 2018-03-27 | — | — | CN | disclosed |
| EP-3294418-A1 | TARGETED SELECTION OF PATIENTS FOR TREATMENT WITH CORTISTATIN DERIVATIVES | President and Fellows of Harvard College (US) | 2018-03-21 | — | — | EP | disclosed |
| EP-3294298-A1 | CORTISTATIN ANALOGUES, SYNTHESES, AND USES THEREOF | President and Fellows of Harvard College (US) | 2018-03-21 | — | — | EP | disclosed |
| WO-2016182904-A1 | TARGETED SELECTION OF PATIENTS FOR TREATMENT WITH CORTISTATIN DERIVATIVES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-11-17 | — | — | WO | disclosed |
| WO-2016182932-A1 | CORTISTATIN ANALOGUES, SYNTHESES, AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-11-17 | — | — | WO | disclosed |
| CN-103435581-A | Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds, the use thereof and method for the production thereof | BOEHRINGER INGELHEIM INT | 2013-12-11 | — | — | CN | disclosed |
| CN-101193903-B | Process for preparing glucopyranosyl-substituted benzylbenzene derivatives and intermediates thereof | BOEHRINGER INGELHEIM INT | 2013-10-30 | — | — | CN | disclosed |
| CN-103030617-A | Glucopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture | BOEHRINGER INGELHEIM INT | 2013-04-10 | — | — | CN | disclosed |
| CN-102351918-A | Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing said compounds, their use and process for their preparation | BOEHRINGER INGELHEIM INT | 2012-02-15 | — | — | CN | disclosed |
| US-20110087034-A1 | Organic Semiconductor Material | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2011-04-14 | — | — | US | disclosed |
| CN-101939325-A | Organic semiconductor material | SUMITOMO CHEMICAL CO | 2011-01-05 | — | — | CN | disclosed |
| EP-2248818-A1 | ORGANIC SEMICONDUCTOR MATERIAL | Sumitomo Chemical Company, Limited (JP) | 2010-11-10 | — | — | EP | disclosed |
| CN-101437807-A | Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing said compounds, their use and process for their preparation | BOEHRINGER INGELHEIM INT (DE) | 2009-05-20 | — | — | CN | disclosed |
| CN-101384576-A | Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture | BOEHRINGER INGELHEIM INT (DE) | 2009-03-11 | — | — | CN | disclosed |
| CN-101193903-A | Process for preparing glucopyranosyl-substituted benzylbenzene derivatives and intermediates thereof | BOEHRINGER INGELHEIM INT (DE) | 2008-06-04 | — | — | CN | disclosed |