Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5028029 | 0.94 | SYK (0.56) | SYK | |
| SCHEMBL9106426 | 0.85 | SYK (0.43) | SYKIRAK4 | |
| SCHEMBL18925839 | 0.85 | SYK (0.53) | SYK | |
| SCHEMBL9105352 | 0.84 | SYK (0.47) | SYKIRAK4 | |
| SCHEMBL5028211 | 0.84 | SYK (0.58) | SYK | |
| SCHEMBL5028187 | 0.83 | SYK (0.59) | SYKIRAK4 | |
| SCHEMBL5027635 | 0.83 | SYK (0.53) | SYKIRAK4 | |
| SCHEMBL2714347 | 0.82 | SYK (0.49) | SYK | |
| SCHEMBL14929556 | 0.81 | SYK (0.72) | SYK | |
| SCHEMBL9109091 | 0.81 | SYK (0.72) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902688-B2 | Benzamides and nicotinamides as Syk modulators | PORTOLA PHARMACEUTICALS, INC. (US) | 2018-02-27 | — | — | US | disclosed |
| US-8846928-B2 | Benzamides and nicotinamides as Syk modulators | PORTOLA PHARMACEUTICALS, INC. (US) | 2014-09-30 | — | — | US | disclosed |