⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538412 | 0.88 | INPPL1 (0.32) | — | |
| Tetrazole SCHEMBL5041698 | 0.86 | — | — | |
| Tetrazole SCHEMBL5041695 | 0.86 | — | — | |
| Tetrazole SCHEMBL3922918 | 0.86 | — | — | |
| Tetrazole SCHEMBL6400674 | 0.85 | — | — | |
| Tetrazole SCHEMBL10416579 | 0.73 | FLT3 (0.36) | — | |
| SCHEMBL79536 | 0.72 | DAO (0.33) | — | |
| Phosphoric Acid SCHEMBL7161584 | 0.71 | NR4A2 (0.39) | — | |
| SCHEMBL6507136 | 0.69 | DAO (0.50) | — | |
| Tetrazole SCHEMBL28110299 | 0.68 | F7 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130251735-A1 | SCLEROSTIN AND THE INHIBITION OF WNT SIGNALING AND BONE FORMATION | ENZO BIOCHEM INC (US) | 2013-09-26 | — | — | US | disclosed |
| US-8461155-B2 | Binding to LRP5 or LRP6 receptor; promoting growth with DAN family bone morphogenetic protein antagonist | UNIVERSITY OF CONNECTICUT (US) | 2013-06-11 | — | — | US | disclosed |
| EP-2248528-B1 | Use of compositions comprising Dkk2 and fragments thereof for the stimulation or enhancement of bone formation | ENZO THERAPEUTICS INC (US) | 2013-01-02 | — | — | EP | disclosed |
| US-8343922-B2 | Compositions and methods for the stimulation or enhancement of bone formation and the self-renewal of cells | ENZO BIOCHEM, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-20120115787-A9 | Sclerostin and the inhibition of WNT signaling and bone formation | CONNECTICUT UNIVERSITY OF | 2012-05-10 | — | — | US | disclosed |
| US-20110086021-A1 | Sclerostin and the inhibition of WNT signaling and bone formation | ENZO THERAPEUTICS, INC., C/O ENZO BIOCHEM, INC. (US) | 2011-04-14 | — | — | US | disclosed |
| EP-2248528-A1 | Use of compositions comprising Dkk2 and fragments thereof for the stimulation or enhancement of bone formation | ENZO THERAPEUTICS, INC. (US) | 2010-11-10 | — | — | EP | disclosed |
| US-20100074891-A1 | Sclerostin and the inhibition of Wnt signaling and bone formation | WU DIANQING DAN | 2010-03-25 | — | — | US | disclosed |
| EP-1755643-A4 | COMPOSITIONS AND METHODS FOR THE STIMULATION OR ENHANCEMENT OF BONE FORMATION AND THE SELF-RENEWAL OF CELLS | ENZO THERAPEUTICS INC (US) | 2009-08-19 | — | — | EP | disclosed |
| EP-1883418-A2 | SCLEROSTIN AND THE INHIBITION OF WNT SIGNALING AND BONE FORMATION | ENZO BIOCHEM, INC. (US) | 2008-02-06 | — | — | EP | disclosed |
| EP-1755643-A2 | COMPOSITIONS AND METHODS FOR THE STIMULATION OR ENHANCEMENT OF BONE FORMATION AND THE SELF-RENEWAL OF CELLS | ENZO THERAPEUTICS, INC. (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2006102070-A2 | SCLEROSTIN AND THE INHIBITION OF WNT SIGNALING AND BONE FORMATION | ENZO BIOCHEM, INC. (US) | 2006-09-28 | — | — | WO | disclosed |
| US-20060030523-A1 | Sclerostin and the inhibition of WNT signaling and bone formation | WU DIANQING D | 2006-02-09 | — | — | US | disclosed |
| WO-2005112981-A2 | COMPOSITIONS AND METHODS FOR THE STIMULATION OR ENHANCEMENT OF BONE FORMATION AND THE SELF-RENEWAL OF CELLS | ENZO THERAPEUTICS, INC. (US) | 2005-12-01 | — | — | WO | disclosed |
| US-20050261181-A1 | Compositions and methods for the stimulation or enhancement of bone formation and the self-renewal of cells | ENZO LIFE SCIENCES, INC. | 2005-11-24 | — | — | US | disclosed |