Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1614236 | 0.87 | PIK3CA (0.53) | PIK3CAPDE4BPIK3CDPIK3CB | |
| SCHEMBL12714084 | 0.86 | AKT1 (0.41) | PIK3CAPDE4B | |
| SCHEMBL1613818 | 0.83 | AKT1 (0.36) | PIK3CAPDE4B | |
| SCHEMBL12714107 | 0.83 | AKT1 (0.36) | PIK3CAPDE4B | |
| SCHEMBL12743262 | 0.83 | PDE4B (0.37) | PIK3CAPDE4BPIK3CDPIK3CB | |
| SCHEMBL1613305 | 0.81 | MAP3K14 (0.38) | PIK3CAPDE4BPIK3CDPIK3CB | |
| SCHEMBL1612030 | 0.80 | MAP3K14 (0.54) | PIK3CAPDE4BPIK3CDPIK3CB | |
| SCHEMBL1614854 | 0.79 | MAP3K14 (0.40) | PIK3CAPDE4B | |
| SCHEMBL1614023 | 0.76 | MAP3K14 (0.37) | PDE4B | |
| SCHEMBL1612750 | 0.76 | PIK3CA (0.49) | PIK3CAPDE4BPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | NFKBIA, MAP3K1, MAP3K2 | PIK3CA 334/4885PDE4B 1857/4885PIK3CD 335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.