Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.74 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6521494 | 0.85 | BRAF (1.00) | BRAF | |
| SCHEMBL1494592 | 0.79 | BRAF (1.00) | BRAF | |
| SCHEMBL13977474 | 0.75 | JAK2 (0.72) | BRAFMAPK13MAPK9MAPK12 | |
| SCHEMBL1494655 | 0.75 | BRAF (1.00) | BRAF | |
| SCHEMBL12830512 | 0.73 | BRAF (0.82) | BRAF | |
| SCHEMBL1494598 | 0.72 | BRAF (0.76) | BRAF | |
| SCHEMBL6521524 | 0.71 | BRAF (1.00) | BRAF | |
| SCHEMBL4585531 | 0.71 | MAPK14 (0.57) | BRAFMAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL4187423 | 0.70 | JAK2 (0.76) | MAPK13MAPK9MAPK12 | |
| SCHEMBL1494679 | 0.70 | BRAF (0.80) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470528-B1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | NOVARTIS AG (CH) | 2014-10-01 | — | — | EP | disclosed |