Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CYP2A13 | Q16696 | 6/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6340603 | 0.83 | CYP2C9 (0.56) | CYP2C9ALOX15HSD17B10CYP2A13ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6340504 | 0.82 | CYP2C9 (0.54) | CYP2C9ALOX15HSD17B10CYP2A13ALDH1A1 | |
| SCHEMBL9424160 | 0.81 | CYP2A13 (0.71) | CYP2C9ALOX15HSD17B10CYP2A13HIF1A | |
| SCHEMBL13957652 | 0.81 | CYP2C9 (0.53) | CYP2C9ALOX15HSD17B10CYP2A13ALDH1A1 | |
| SCHEMBL19175045 | 0.81 | HSD17B10 (0.53) | CYP2C9ALOX15HSD17B10CYP2A13ALDH1A1 | |
| SCHEMBL15546497 | 0.81 | CYP2A13 (0.61) | CYP2C9ALOX15HSD17B10CYP2A13HIF1A | |
| SCHEMBL2338990 | 0.80 | CYP2A13 (0.64) | CYP2C9ALOX15HSD17B10CYP2A13ALDH1A1 | |
| SCHEMBL21765349 | 0.79 | HSD17B10 (0.51) | CYP2C9ALOX15HSD17B10CYP2A13HIF1A | |
| Hydrochloric Acid SCHEMBL9423982 | 0.78 | CYP2A13 (0.62) | CYP2C9ALOX15HSD17B10CYP2A13ALDH1A1 | |
| SCHEMBL1438683 | 0.77 | CYP2A13 (0.66) | CYP2C9ALOX15HSD17B10CYP2A13HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315751-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | Amgen Inc. (US) | 2011-05-04 | — | — | EP | disclosed |
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | NFKBIA, MAP3K1, MAP3K2 | CYP2C9 3576/4885ALOX15 512/4885HSD17B10 1123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.