Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | TP53 | P04637 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16136261 | 0.90 | KDM4E (0.67) | KDM4EGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16136219 | 0.90 | KDM4E (0.57) | KDM4EGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16136221 | 0.81 | KDM4E (0.55) | KDM4EGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16311057 | 0.81 | KDM4E (0.77) | KDM4EGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16136100 | 0.80 | KDM4E (0.67) | KDM4EGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16136184 | 0.80 | KDM4E (0.67) | KDM4EGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16136243 | 0.79 | MAPT (0.54) | KDM4EGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16111116 | 0.78 | KDM4E (0.61) | KDM4EGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16136192 | 0.77 | KDM4E (0.63) | KDM4EGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16136046 | 0.77 | KDM4E (0.74) | KDM4EGAAALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014160440-A1 | PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB (US) | 2014-10-02 | — | — | WO | disclosed |