Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 5/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12317150 | 0.79 | NPY5R (0.40) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1484853 | 0.79 | PIK3CA (0.39) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL12343377 | 0.79 | BRD9 (0.51) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1484936 | 0.78 | PIK3CA (0.41) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL12317155 | 0.69 | PIK3CA (0.47) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1484670 | 0.69 | PIK3CA (0.70) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1484738 | 0.69 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1484834 | 0.68 | PIK3CA (0.47) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1484890 | 0.67 | PIK3CA (0.41) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1485047 | 0.61 | PIK3CA (0.62) | PIK3CAPIK3CBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483277-B1 | BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2015-12-02 | — | — | EP | disclosed |
| EP-2784078-A1 | Benzoxepin pi3k inhibitor compounds and methods of use | F. Hoffmann-La Roche AG (CH) | 2014-10-01 | — | — | EP | disclosed |