Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 19/20 | 1.00 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21859092 | 1.00 | MAP3K14 (1.00) | MAP3K14MAP4K4PAK4 | |
| SCHEMBL31300227 | 1.00 | MAP3K14 (1.00) | MAP3K14MAP4K4PAK4 | |
| SCHEMBL1613706 | 0.87 | MAP3K14 (0.77) | MAP3K14MAP4K4PAK4 | |
| SCHEMBL1614558 | 0.85 | MAP3K14 (0.73) | MAP3K14MAP4K4PAK4 | |
| SCHEMBL1612370 | 0.83 | MAP3K14 (0.71) | MAP3K14MAP4K4PAK4 | |
| SCHEMBL12743357 | 0.83 | MAP3K14 (0.70) | MAP3K14MAP4K4 | |
| SCHEMBL1613725 | 0.77 | MAP3K14 (0.63) | MAP3K14MAP4K4PAK4 | |
| SCHEMBL1612794 | 0.77 | MAP3K14 (0.62) | MAP3K14MAP4K4PAK4 | |
| SCHEMBL1613487 | 0.72 | MAP3K14 (0.56) | MAP3K14MAP4K4PAK4 | |
| SCHEMBL11971003 | 0.72 | MAP3K14 (0.67) | MAP3K14MAP4K4PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210355221-A1 | Targeting the Non-Canonical NFkB Pathway in Cancer Immunotherapy | THE GENERAL HOSPITAL CORPORATION | 2021-11-18 | — | — | US | claimed |
| WO-2020082016-A1 | TARGETING THE NON-CANONICAL NFKB PATHWAY IN CANCER IMMUNOTHERAPY | THE GENERAL HOSPITAL CORPORATION (US) | 2020-04-23 | — | — | WO | claimed |
| US-20240415801-A1 | Methods and Compositions for Treating Fibroids | LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER | 2024-12-19 | — | — | US | disclosed |
| US-20210355221-A1 | Targeting the Non-Canonical NFkB Pathway in Cancer Immunotherapy | THE GENERAL HOSPITAL CORPORATION | 2021-11-18 | — | — | US | disclosed |
| WO-2020082016-A1 | TARGETING THE NON-CANONICAL NFKB PATHWAY IN CANCER IMMUNOTHERAPY | THE GENERAL HOSPITAL CORPORATION (US) | 2020-04-23 | — | — | WO | disclosed |
| EP-2315751-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | Amgen Inc. (US) | 2011-05-04 | — | — | EP | disclosed |
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | NFKBIA, MAP3K1, MAP3K2 | MAP3K14 17/4885MAP4K4 57/4885PAK4 323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.