Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | SCN1A | P35498 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17584922 | 0.93 | CYP3A4 (0.43) | CYP3A4ABCB1MEN1KMT2AABCC1 | |
| SCHEMBL16138815 | 0.93 | CYP3A4 (0.43) | CYP3A4ABCB1MEN1KMT2AABCC1 | |
| SCHEMBL3000903 | 0.92 | CYP3A4 (0.59) | CYP3A4ABCB1MEN1KMT2AABCC1 | |
| SCHEMBL16139149 | 0.91 | CYP3A4 (0.49) | CYP3A4ABCB1MEN1KMT2AABCC1 | |
| SCHEMBL16139093 | 0.89 | CYP3A4 (0.47) | CYP3A4ABCB1MEN1KMT2AABCC1 | |
| SCHEMBL16139148 | 0.88 | CYP3A4 (0.49) | CYP3A4ABCB1MEN1KMT2AABCC1 | |
| SCHEMBL25985712 | 0.88 | ABCB1 (0.36) | CYP3A4ABCB1MEN1KMT2AABCC1 | |
| SCHEMBL16139053 | 0.86 | CYP3A4 (0.56) | CYP3A4ABCB1MEN1KMT2AABCC1 | |
| SCHEMBL16138825 | 0.84 | CYP3A4 (0.42) | CYP3A4ABCB1MEN1KMT2AABCC1 | |
| SCHEMBL17584927 | 0.84 | CYP3A4 (0.43) | CYP3A4ABCB1MEN1KMT2AABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230255923-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | MILESTONE PHARMACEUTICALS INC (CA) | 2023-08-17 | — | — | US | disclosed |
| US-10010522-B2 | Short acting phenylalkylamine calcium channel blockers and uses thereof | MILESTONE PHARMACEUTICALS INC. (CA) | 2018-07-03 | — | — | US | disclosed |
| US-10010523-B2 | Short acting phenylalkylamine calcium channel blockers and uses thereof | MILESTONE PHARMACEUTICALS INC. (CA) | 2018-07-03 | — | — | US | disclosed |
| US-10010524-B2 | Short acting phenylalkylamine calcium channel blockers and uses thereof | MILESTONE PHARMACEUTICALS INC. (CA) | 2018-07-03 | — | — | US | disclosed |
| US-20170312242-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ACQUIOM AGENCY SERVICES, LLC | 2017-11-02 | — | — | US | disclosed |
| US-20170312241-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ACQUIOM AGENCY SERVICES, LLC | 2017-11-02 | — | — | US | disclosed |
| US-20170312243-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ACQUIOM AGENCY SERVICES, LLC | 2017-11-02 | — | — | US | disclosed |
| US-9737503-B2 | Short acting phenylalkylamine calcium channel blockers and uses thereof | MILESTONE PHARMACEUTICALS INC. (CA) | 2017-08-22 | — | — | US | disclosed |
| US-20160374982-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ACQUIOM AGENCY SERVICES, LLC | 2016-12-29 | — | — | US | disclosed |
| US-9463179-B2 | Short acting phenylalkylamine calcium channel blockers and uses thereof | MILESTONE PHARMACEUTICALS INC. (CA) | 2016-10-11 | — | — | US | disclosed |
| US-20160074354-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ACQUIOM AGENCY SERVICES, LLC | 2016-03-17 | — | — | US | disclosed |
| US-9227918-B2 | Short acting phenylalkylamine calcium channel blockers and uses thereof | MILESTONE PHARMACEUTICALS (CA) | 2016-01-05 | — | — | US | disclosed |
| US-20140296335-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ACQUIOM AGENCY SERVICES, LLC | 2014-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230255923-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | CYP3A4 2169/4885ABCB1 1819/4885MEN1 4378/4885 |
| US-20160374982-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | CYP3A4 2169/4885ABCB1 1819/4885MEN1 4378/4885 |
| US-20170312243-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | CYP3A4 2169/4885ABCB1 1819/4885MEN1 4378/4885 |
| US-10010524-B2 | Short acting phenylalkylamine calcium channel blockers and uses thereof | ORAI1, ATP2A1, RYR2 | CYP3A4 2169/4885ABCB1 1819/4885MEN1 4378/4885 |
| US-20140296335-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | CYP3A4 2169/4885ABCB1 1819/4885MEN1 4378/4885 |
| US-10010522-B2 | Short acting phenylalkylamine calcium channel blockers and uses thereof | ORAI1, ATP2A1, RYR2 | CYP3A4 2169/4885ABCB1 1819/4885MEN1 4378/4885 |
| US-20160074354-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | CYP3A4 2169/4885ABCB1 1819/4885MEN1 4378/4885 |
| US-20170312241-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | CYP3A4 2169/4885ABCB1 1819/4885MEN1 4378/4885 |
| US-10010523-B2 | Short acting phenylalkylamine calcium channel blockers and uses thereof | ORAI1, ATP2A1, RYR2 | CYP3A4 2169/4885ABCB1 1819/4885MEN1 4378/4885 |
| US-20170312242-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | CYP3A4 2169/4885ABCB1 1819/4885MEN1 4378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.