Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 3/20 | 0.46 |
| ▸ | MAP3K14 | Q99558 | 17/20 | 0.45 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1614853 | 1.00 | PAK4 (0.46) | PAK4MAP3K14PIKFYVEPRKD1 | |
| SCHEMBL1613974 | 1.00 | PAK4 (0.46) | PAK4MAP3K14PIKFYVEPRKD1 | |
| SCHEMBL1613528 | 0.92 | PAK4 (0.49) | PAK4MAP3K14PRKD1 | |
| SCHEMBL1613491 | 0.87 | MAP3K14 (0.47) | PAK4MAP3K14PRKD1 | |
| SCHEMBL1611642 | 0.86 | MAP3K14 (0.50) | PAK4MAP3K14PRKD1 | |
| SCHEMBL12743927 | 0.85 | KDM4E (0.37) | MAP3K14PIKFYVE | |
| SCHEMBL12743926 | 0.85 | KDM4E (0.37) | MAP3K14PIKFYVE | |
| SCHEMBL1613510 | 0.85 | MAP3K14 (0.49) | PAK4MAP3K14PRKD1 | |
| SCHEMBL1612220 | 0.85 | MAP3K14 (0.49) | PAK4MAP3K14PRKD1 | |
| SCHEMBL1612226 | 0.85 | MAP3K14 (0.49) | PAK4MAP3K14PRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315751-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | Amgen Inc. (US) | 2011-05-04 | — | — | EP | disclosed |
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | NFKBIA, MAP3K1, MAP3K2 | PAK4 323/4885MAP3K14 17/4885PIKFYVE 126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.